Targeted compound helps recurrent prostate cancer patients

A study appearing in the Journal of Clinical Oncology reveals there may be something out there that can extend the lives of patients with recurrent prostate cancer.

This something is a new class of anti-cancer targeted drugs that scientists at Cedars-Sinai Medical Center in Los Angeles say are quite promising, despite their ineffectiveness in some prostate cancer patients with no previous chemotherapy treatment.

Pertuzumab, a molecular targeted compound that has been used successfully in ovarian cancer patients, has been shown to block the human epidermal growth factor receptor family by binding to and inhibiting the function of HER2 receptors. They essentially block a key pathway that leads to cancer growth. And this blockage can possibly offer a better, longer life for recurrent prostate cancer patients whose diseases no longer respond to traditional chemotherapy.

Pertuzumab, marketed under the brand name Omnitarg by Roche and Genentech, is just one of many targeted cancer therapies that give researchers hope that cancer may one day be a lifetime disease that can be skillfully managed.

Larynx cancer linked to asbestos

The U.S. government's Institute of Medicine reported that asbestos, which is accepted as a cause of a number of respiratory ailments including lung cancer, may also be a source for laryngeal cancer. The larynx produces the sound of your voice. Each year in the United States, more than 10,000 people learn they have larynx cancer. Men are four times more likely than women to get cancer of the larynx. Occupational related issues are certainly a factor with mechanics, construction, and other jobs that handle asbestos.

A series of studies have found that certain cancers of the throat and lungs are similar, so the U.S. Senate asked the institute to investigate a potential link between asbestos and other upper-body cancers. Asbestos is also linked to mesothelioma which is a rare cancer that attacks the lining of the chest.

Smokers and smokers that drink alcohol are even more at risk to develop cancer of the larynx. Symptoms of larynx cancer are hoarseness or other voice changes,lump in the neck, a sore throat or feeling that something is stuck in your throat, a cough that does not go away, breathing problems, bad breath, earaches, and weight loss.

Gwyneth Paltrow fights cancer curse with food

Actress Gwyneth Paltrow has lost five family members to cancer -- and she fears the disease may one day strike her. So she's taking action now and is trying to beat back the cancer curse that seems to loom over her loved ones.

Ever since losing her famous father in 2002 to throat cancer, Paltrow has been approaching life from a biological perspective.

"Cancer has been the curse of my family,"she said. "I am challenging these evil genes by natural means. I am convinced that by eating biological foods it is possible to avoid the growth of tumors. I began this crusade soon after my father's death. Since then the fight against tumors has been my mission."

Paltrow and her husband, Coldplay's Chris Martin, have embraced a strict vegetarian diet for their young family, and they hope their commitment to healthy eating will ward off the illness they fear may be headed right for them.

Advanced breast cancer drug combination more effective

Researchers in Spain conducted a Phase III clinical trial called GEICAM. They wanted to compare different chemotherapy regimes in women diagnosed with metastatic breast cancer. The trial included 252 women who had already been treated with anthracyclines and taxanes and experienced a recurrence.

One group of women was treated with Gemzar (gemcitabine) and Navelbine (vinorelbine), the other group was treated with Navelbine alone. The results were published in Lancet Oncology that states the combination of the two drugs improves progression free survival. It was also mentioned that this combination however did not improve overall survival.

When cancer recurs following treatment with anthracyclines and taxanes, some of the strongest chemotherapies for breast cancer, patients have limited treatment options. Researchers continue to search for different chemotherapy combinations that are effective against recurrent breast cancer.

The researchers concluded that anticancer responses were 36 percent for patients treated with Gemzar/Navelbine and 26 percent for patients treated with Navelbine alone.

American Cancer Society receives largest ever donation

International pharmaceutical company AstraZeneca is donating $10 million to the American Cancer Society (ACS). The donation is one of the largest gifts ever received by the ACS and will help provide support for patients in United States hospitals.

Support will come in the form of specially-trained ACS employees who will work in 60 different hospitals and cancer centers and will offer social, emotional, financial, and transportation assistance in medically underserved Atlanta areas.

London-based AstraZeneca, maker of breast cancer drug tamoxifen and other breast and prostate cancer drugs, made $26 billion in sales last year, the same year the company gave $7 million to a Boston Cancer Society for the development of a Hope Lodge.

Britney's bald head brings back bitter memories

Recent news reports reveal Britney Spears recently checked in and then checked right out of Eric Clapton's Crossroads Centre rehab facility in Antigua. And now that Spears has returned to Los Angeles, something else is being revealed -- her bald head.

Apparently Spears chose to shave her head and add a few new tattoos to her body in honor of her speedy return back home. Why, I am not sure. But the image of her shiny scalp brings back bitter memories of my own bald head that had nothing to do with free will and choice and had everything to do with cancer.

I hated my bald head, took great pains to cover it at all times, and found nothing beautiful about the prominent display of flesh that surrounded my face. I can see beauty in other bald heads -- and I think Britney looks just fine with her new look -- but I was blind to it when looking at myself in the mirror. I hated my bald head.

"What are you going to do with your hair?" one of my co-workers asked me the other day.

"I'm letting it grow," I told her. "And grow and grow and grow," I thought to myself.

This co-worker seemed sad I was growing my hair. She said she really liked it short, with its tight curls and flat-to-my-head style. Many people have told me this same thing, that I look good with short hair. And maybe I do. Maybe I look good bald too. But I never wished for short hair. I never wished for no hair. And so I am getting back at cancer by letting my hair grow and grow and grow. It's my revenge of sorts.

Bald is just not for me. So I'm relinquishing all rights I have to this extreme hair fashion to those who choose it. To those who wear it well. To Britney.

Cancer drug Nexavar so good clinical trials end early

Cancer drug Nexavar has made its point. It can help people with liver cancer survive longer.

Bayer Pharmaceuticals and Onyx Pharmaceuticals announced Monday that advanced stage clinical trials for this drug will end early. And now patients in the placebo arm of the study can begin treatment with the actual drug.

It's been a long road for researchers who have been searching for a liver cancer treatment that can target tumors with minimal side effects while extending life for months or even years.

It is estimated that 16,780 people in the United States will die from liver cancer in 2007 -- and it seems Nexavar, a drug initially predicted to fail when used for liver cancer -- may help save some of these lives.

Bayer and Onyx are planning to pursue FDA approval for this drug that has already been approved for kidney cancer.

Sunday Seven: Seven fears left by breast cancer

Cancer-related fear once consumed my mind. Now it sits lodged in the back of my brain and only presents itself on rare occasions.

I handle my fears so much better now than when cancer was new and fresh and raw. My fears hardly ever cause me real anxiety, they don't cripple my mental functioning anymore, and more than ever, they serve to focus my efforts in life. When fear strikes, it's usually a wake-up call of sorts, a reminder to leave no stone unturned, a summons to keep on living.

Although so much less threatening than they once were, my fears still exist. And I like to review them once in awhile, lose myself in a little emotional housekeeping, tidy up some of the mess cancer made. I always feel better when things are in order -- fears included.

• I fear a breast cancer recurrence, the return of a tumor that rises to the surface of my skin and presents itself again underneath my fingertips -- or in my worst-case scenario is lost among dense breast tissue, undetected by self-exam, and caught too late by some combination of mammogram, ultrasound, and MRI.

• I fear more than anything another cancer -- something entirely different from breast cancer, something buried in my body and not as responsive as breast cancer to treatment. I am prepared for a second visit from breast cancer because I know how to proceed, know I will succumb to treatment that is familiar, know I will remove both breasts in the most radical of life-saving approaches. But cancer in my lungs, brain, bones, blood, ovaries is out of my realm. And these cancers -- among many others -- really scare me.
  

• I fear that my mom and my sister -- my first-degree female relatives -- will one day follow in my breast cancer footsteps. I once thought family history trickled down from above, from older family members. Now I know the disease can start with anyone. I am the anyone in my family. I am the reason my mom and sister are closely watched and monitored and tested. I am the one that put the fear of cancer into their hearts and minds -- and into mine.
  

• I fear having another baby. I fear the return of cancer during pregnancy, leaving me with difficult choices regarding my health and my baby's health. I fear cancer returning after a baby is born, leaving me with one more child and more treatment to manage. I fear another cancer would lead to a decreased chance of survival and another baby would leave my husband feeling stranded should I die too soon. And I fear having a baby girl who would inherit the very real chance of developing breast cancer at some time during her life.
  

• I fear not having another baby. I fear the regret I may feel one day, perhaps 50 years from now when I am healthy and cancer-free and without the child I longed for. I fear I am being overly cautious, too tentative, a bit selfish. A fellow cancer survivor once wrote me, "I learned that my family continues, even if I do not. I also learned that they are at least as tough as I am so will cope with the genes I pass to them and their own cancer battles if needed. Finally, I learned they look out for each other just as I looked out for them. No matter what your future, you will never regret giving another child a place in your family." I fear this man may be right.
  

• I fear the potential long-term effects of treatment. I fear the chemotherapy that saved my life in the short-term may come to haunt me in the long run. I fear the radiation that zapped my breast and a piece of my lung and part of my ribs and possibly my heart will cause me problems in the future. I fear the effects of Herceptin -- the drug that dripped into my veins for one whole year with the purpose of keeping cancer at bay -- and worry my heart my fail me when I am old and gray because of the toxicity of this drug.
  

• I fear dying at a young age. I fear leaving my children before they are grown. I fear leaving my husband a single parent, my mom someone who has lost a child, and my sister an only child. I have been told over and over again that my chances of survival are great, fantastic even. I have a 93 percent chance of not dying from breast cancer. This does seem great -- until I take into account that this percentage is good for only five years. My five years will expire when I am 39 years old. What happens then, I am not sure. The only thing I am sure about is that five years is not enough time. I want more, need more, demand more. Yet I fear my days may be numbered.
  

These are the fears that keep me focused. And while they are sometimes not-so-pleasant, I am in no hurry to resolve any of them. I am thankful really to have these fears swirling in my head -- because it means I am alive. And for me, being alive with fears is better than not being alive at all.

Farrah Fawcett is 60 -- and cancer-free

Farrah Fawcett turned 60 on Friday. And she's been celebrating this milestone along with a very important message she just received -- she is cancer-free.

Fawcett, former star of the hit 1970s TV drama Charlie's Angels, was diagnosed with anal cancer four months ago and has been enduring an aggressive treatment protocol to treat the disease -- a treatment that appears to have worked.

Her physician, Dr. Gary Gitnick at the University of California, Los Angeles, medical school reports Fawcett "has had a full and complete response to treatment." Recent tests show her cancer is gone -- and Gitnick calls her prognosis excellent.

Fawcett calls the whole experience a hopeful one.

"In the face of excruciating pain and uncertainty, I never lost hope," she said. "I hope that my news might offer some level of inspiration to others who unfortunately must continue to fight the disease."

Happy World Cancer Day!

I guess the concept is happy -- the public urging for our world's policy makers to make cancer a top priority -- but the fact that becomes all too apparent on this World Cancer Day is quite sobering. More than seven million people die from cancer and close to 11 million new cases are diagnosed worldwide each year. In 2006, cancer killed more people than AIDS, malaria, and tuberculosis combined.

So today is both happy and sad. But for now, let's focus on the happy.

The Geneva-based International Union Against Cancer (UICC) and member organizations in 86 countries are launching a five-year campaign to impart life lessons to children so they can prevent cancer later in life. Parents are critical in this campaign and must take an active role in teaching their children techniques for saving their lives.

Forty-three percent of cancer cases can be prevented through healthy lifestyles that begin in childhood. The World Cancer Campaign slogan -- Today's Children, Tomorrow's World -- underscores the possibility that a concerted effort among world leaders, parents, and their children can make a real difference through four key actions -- providing a smoke-free environment for children; ensuring children keep physically active, eat a healthy diet, and avoid obesity; educating children about vaccines for virus-related liver and cervical cancers; and limiting children's exposure to the sun.

Former First Lady Barbara Bush, Her Royal Highness Lalla Slama of Morocco, Nigerian President Olusegun Obasanjo, and tennis star Steffi Graf are some of the powerful voices powering this campaign that UICC president Dr. Franco Cavalli says can save so many lives if embraced by those at the highest decision-making levels.

"Complacency and inaction on the part of world community will effectively contribute to more than 10 million deaths every year by 2020," he said.